Article

Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome

2024-07-27

Abstract excerpt

<h4>SUMMARY</h4> Single-cell CRISPR screens link genetic perturbations to transcriptional states, but high-throughput methods connecting these induced changes to their regulatory foundations are limited. Here we introduce Multiome Perturb-seq, extending single-cell CRISPR screens to simultaneously measure perturbation-induced changes in gene expression and chromatin accessibility. We apply Multiome Perturb-seq in...

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Literature Corpus work: d96600c4-9279-55b0-ac54-95155ee64006
DOI: 10.1101/2024.07.26.605307

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