Article

A Perturbation Cell Atlas of Human Induced Pluripotent Stem Cells

2024-11-04

Abstract excerpt

<h4>SUMMARY</h4> Towards comprehensively investigating the genotype-phenotype relationships governing the human pluripotent stem cell state, we generated an expressed genome-scale CRISPRi Perturbation Cell Atlas in KOLF2.1J human induced pluripotent stem cells (hiPSCs) mapping transcriptional and fitness phenotypes associated with 11,739 targeted genes. Using the transcriptional phenotypes, we created a minimum d...

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Literature Corpus work: 1de6e502-f373-59dd-bd47-0bbb3d230ff8
DOI: 10.1101/2024.11.03.621734

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