Article

Natural selection shapes codon usage in the human genome

2019-07-01

Abstract excerpt

Synonymous codon usage has been identified as an important determinant of translational efficiency and mRNA stability in model organisms and human cell lines. However, to date, population genetics studies have failed to observe evolutionary constraint on human codon usage, and synonymous variation has been largely overlooked as a component of human genetic diversity. Using genetic sequencing data from nearly 200,0...

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Literature Corpus work: 2802e49a-ca0a-5c72-9251-b08319ad68f5
DOI: 10.1101/688051

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