Article

The codon frustration index as a new metric for mRNA stability, translation efficiency, and rates of protein synthesis

2019-07-04

Abstract excerpt

Taking the human genome as a case of study, we propose a new classification of codons based only on two genomic information. We use the relative synonymous codon usage (RSCU) as a measure of non-uniform usage of synonymous codons. Similarly, we introduce here the relative gene frequencies of cognate tRNAs (RGFCt) to quantify the non-uniform availability of cognate tRNAs in each family of synonymous codons. Using...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ca8a9f2a-ee97-5e03-adba-3e7707d57aa1
DOI: 10.1101/692996

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The codon frustration index as a new metric for mRNA stability, translation efficiency, and rates of protein synthesisDOI 10.1101/692996Read

Natural Selection Shapes Codon Usage in the Human Genome.Semantic proximity Read

Mapping the Inter- and Intra-genic Codon Usage Landscape in <i>Homo sapiens</i>Semantic proximity Read

Synonymous codon usage regulates translation initiationSemantic proximity Read

Natural selection shapes codon usage in the human genomeSemantic proximity Read

Codon usage and amino acid identity are major determinants of mRNA stability in humansSemantic proximity Read

Position-dependent Codon Usage Bias in the Human TranscriptomeSemantic proximity Read

Third-nucleotide codon bias and synonymous codon bias define functional translational programs that shape human tissue and cancer proteomesSemantic proximity Read

A Suite of Foundation Models Captures the Contextual Interplay Between CodonsSemantic proximity Read

Transcriptomic, proteomic and functional consequences of codon usage bias in human cells during heterologous gene expressionSemantic proximity Read

Codon Bias Confers Stability to mRNAs via ILF2 in HumansSemantic proximity Read

Oncogenes have the most distinct codon biases in the genome and codon signatures that oppose tumor suppressor genesSemantic proximity Read

TissueCoCoPUTs: Novel Human Tissue-Specific Codon and Codon-Pair Usage Tables Based on Differential Tissue Gene Expression.Semantic proximity Read