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Article

Estimating the evolutionary fitness of specific synonymous codon changes.

Molecular biology and evolution - 1 Aug 2026

Pavinato Vitor A C, Hey Jody

Abstract excerpt

Synonymous mutations do not alter proteins but undergo natural selection in many species. For Drosophila melanogaster, reports on selection strength vary from undetectable to surprisingly strong. Here we apply a new method to estimate the population selection coefficient (2Ns) for all 134 ordered pairs of synonymous codon changes. The method uses ratios of site frequency spectra for synonymous codon changes and...

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Identifiers

PMID: 42578945
DOI: 10.1093/molbev/msag199
PMCID: PMC13494555

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