Article

Biased gene conversion drives codon usage in human and precludes selection on translation efficiency

2016-11-14

Abstract excerpt

In humans, as in other mammals, synonymous codon usage (SCU) varies widely among genes. In particular, genes involved in cell differentiation or in proliferation display a distinct codon usage, suggesting that SCU is adaptively constrained to optimize translation efficiency in distinct cellular states. However, in mammals, SCU is known to correlate with large-scale fluctuations of GC-content along chromosomes, cau...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e9604173-8189-52b3-9f22-508c7da7e85b
DOI: 10.1101/086447

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Biased gene conversion drives codon usage in human and precludes selection on translation efficiencyDOI 10.1101/086447Read

Recombination, meiotic expression and human codon usage.Semantic proximity Read

Phylogenetic patterns of GC-biased gene conversion in placental mammals and the evolutionary dynamics of recombination landscapes.Semantic proximity Read

Mapping the Inter- and Intra-genic Codon Usage Landscape in <i>Homo sapiens</i>Semantic proximity Read

GC-content evolution in bacterial genomes: the biased gene conversion hypothesis expandsSemantic proximity Read

Evolution of GC-biased gene conversion by natural selection.Semantic proximity Read

The evolution of GC-biased gene conversion by means of natural selectionSemantic proximity Read

Natural Selection Shapes Codon Usage in the Human Genome.Semantic proximity Read

Natural selection shapes codon usage in the human genomeSemantic proximity Read

The GC-content at the 5’ends of human protein-coding genes is undergoing mutational decaySemantic proximity Read

Explaining complex codon usage patterns with selection for translational efficiency, mutation bias, and genetic drift.Semantic proximity Read

Population dynamics of GC-changing mutations in humans and great apesSemantic proximity Read

Selective and mutational patterns associated with gene expression in humans: influences on synonymous composition and intron presence.Semantic proximity Read