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Article

Recombination, meiotic expression and human codon usage.

eLife - 15 Aug 2017

Pouyet Fanny, Mouchiroud Dominique, Duret Laurent, Sémon Marie

Abstract excerpt

Synonymous codon usage (SCU) varies widely among human genes. In particular, genes involved in different functional categories display a distinct codon usage, which was interpreted as evidence that SCU is adaptively constrained to optimize translation efficiency in distinct cellular states. We demonstrate here that SCU is not driven by constraints on tRNA abundance, but by large-scale variation in GC-content,...

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Identifiers

PMID: 28826480
DOI: 10.7554/eLife.27344
PMCID: PMC5576983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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