Article

NOX2-Derived Hydrogen Peroxide Impedes the AMPK/Akt-mTOR Signaling Pathway in Parkinson's Disease in Vitro Models

2021-08-05

Abstract excerpt

<title>Abstract</title> <p>Oxidative stress is closely related to the pathogenesis of Parkinson's disease (PD), a typical neurodegenerative disease. NADPH oxidase 2 (NOX2) is involved in hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) generation. Recently, we have reported that H<sub>2</sub>O<sub>2</sub> and PD toxins, including 6-hydroxydopamine (6-OHDA), 1-Methyl-4-phenylpyridin-1-ium (MPP<sup>+</sup>) and roten...

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Literature Corpus work: 93bfd40b-6b4d-5aa0-8da6-e95ff8422995
DOI: 10.21203/rs.3.rs-767348/v1

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