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Article

Leucine-rich repeat kinase-2 (LRRK2) modulates microglial phenotype and dopaminergic neurodegeneration.

Neurobiology of aging - 1 Jul 2020

Dwyer Zach, Rudyk Chris, Thompson Ashley, Farmer Kyle, Fenner Barbara, Fortin Teresa, Derksen Alexa, Sun Hongyu, Hayley Shawn

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) is a common gene implicated in Parkinson's disease and many inflammatory processes. Thus, we assessed the role of LRRK2 in the context of endotoxin (lipopolysaccharide, LPS)-induced inflammation of the substantia nigra together with the environmental toxicant, paraquat, that has been implicated in PD. Here we found that LRRK2 ablation prevented the loss of dopaminergic neurons...

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Source

Identifiers

PMID: 32247534
DOI: 10.1016/j.neurobiolaging.2020.02.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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