Article

NOX2 Inhibition Enables Retention of the Circadian Clock in BV2 Microglia and Primary Macrophages

2022-11-07

Abstract excerpt

<h4>ABSTRACT</h4> Sustained neuroinflammation is a major contributor to the progression of neurodegenerative diseases such as Alzheimer’s (AD) and Parkinson’s (PD) diseases. Neuroinflammation, like other cellular processes, is affected by the circadian clock. Microglia, the resident immune cells in the brain, act as major contributors to neuroinflammation and are under the influence of the circadian clock. Microg...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9bd66bea-267b-5c4b-94d1-a097f0054c20
DOI: 10.1101/2022.11.07.515487

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NOX2 Inhibition Enables Retention of the Circadian Clock in BV2 Microglia and Primary MacrophagesDOI 10.1101/2022.11.07.515487Read

Single-cell variations of circadian clock and immune gene expression in microglia and neurodegenerationSemantic proximity Read

Microglia undergo transcriptional, translational and functional adaptations to dark and light phases in laboratory miceSemantic proximity Read

Bmal1 expression is minimal or absent in human and mouse cerebral microgliaSemantic proximity Read

PPARδ activation in microglia drives a transcriptional response that primes phagocytic function while countering inflammatory activationSemantic proximity Read

TET2 regulates the neuroinflammatory response in microgliaSemantic proximity Read

Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice.Semantic proximity Read

Circadian disruption through light-dark cycle alteration induced Alzheimer's disease-like pathology in miceSemantic proximity Read

NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury.Semantic proximity Read

Macrophage Meets the Circadian Clock: Implication of the Circadian Clock in the Role of Macrophages in Acute Lower Respiratory Tract InfectionSemantic proximity Read

The Role of the NADPH Oxidase NOX2 in Prion PathogenesisSemantic proximity Read

Key features of the innate immune response is mediated by the immunoproteasome in microgliaSemantic proximity Read

Profiles and Dynamics of the Transcriptome of Microglial Cells Reveal their Inflammatory StatusSemantic proximity Read