Article

A distinct signalling circuit upregulates cytotoxic ROS production in a cellular model of Parkinson’s disease: key roles for TRPM2, Zn <sup>2+</sup> and complex III

2024-01-08

Abstract excerpt

<h4>ABSTRACT</h4> Reactive oxygen species (ROS) serve vital physiological functions, but aberrant ROS production contributes to numerous diseases. Unfortunately, therapeutic progress targeting pathogenic ROS has been hindered by limited understanding of whether the mechanisms driving pathogenic ROS differ from those governing physiological ROS generation. To address this knowledge gap, we utilised a cellular mode...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d6865b04-e8a7-5971-b657-180363cb776a
DOI: 10.1101/2024.01.08.574664

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A distinct signalling circuit upregulates cytotoxic ROS production in a cellular model of Parkinson’s disease: key roles for TRPM2, Zn <sup>2+</sup> and complex IIIDOI 10.1101/2024.01.08.574664Read

Decoding Parkinson's Disease: The interplay of cell death pathways, oxidative stress, and therapeutic innovationsSemantic proximity Read

Inter-Organelle Crosstalk in Oxidative Distress: A Unified TRPM2-NOX2 Mediated Vicious Cycle Involving Ca²⁺, Zn²⁺, and ROS AmplificationSemantic proximity Read

A Mitochondrial Inside-Out Iron-Calcium Signal Reveals Drug Targets for Parkinson’s DiseaseSemantic proximity Read

The Multifaceted Roles of Zinc in Neuronal Mitochondrial DysfunctionSemantic proximity Read

What causes the death of dopaminergic neurons in Parkinson's disease?Semantic proximity Read

Mitochondria, calcium and cell death: a deadly triad in neurodegeneration.Semantic proximity Read

The ROS-producing enzyme NADPH oxidase/RBOH is a Ca2+ channel regulated by protons in the eukaryotic kingdomSemantic proximity Read

NOX2-Derived Hydrogen Peroxide Impedes the AMPK/Akt-mTOR Signaling Pathway in Parkinson's Disease in Vitro ModelsSemantic proximity Read

Therapeutic Potential of Heterocyclic Compounds Targeting Mitochondrial Calcium Homeostasis and Signaling in Alzheimer’s Disease and Parkinson’s DiseaseSemantic proximity Read

Parkinson’s Disease: Cells Succumbing to Lifelong Dopamine-related Oxidative Stress and Other Bioenergetic ChallengesSemantic proximity Read

Evaluating Manganese, Zinc, and Copper Metal Toxicity on SH-SY5Y Cells in Establishing an Idiopathic Parkinson’s Disease ModelSemantic proximity Read

Protective role of mitophagy on microglia-mediated neuroinflammatory injury through mtDNA-STING signaling in manganese-induced parkinsonismSemantic proximity Read