Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

P2X7 receptor is critical in α-synuclein--mediated microglial NADPH oxidase activation.

Neurobiology of aging - 1 Jul 2015

Jiang Tianfang, Hoekstra Jake, Heng Xin, Kang Wenyan, Ding Jianqing, Liu Jun, Chen Shengdi, Zhang Jing

Abstract excerpt

Activated microglia are commonly observed in individuals with neurodegenerative disorders, including Parkinson's disease (PD) and are believed to contribute to neuronal death. This process occurs at least due partially to nicotinamide adenine dinucleotide phosphate oxidase (PHOX) activation, which leads to the production of superoxide and oxidative stress. α-Synuclein (α-Syn), a key protein implicated in PD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Cell Death
Share to Dopaminergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microglia

Share to NADPH Oxidase 2

Share to NADPH Oxidases

Share to Proto-Oncogene Proteins c-akt

Share to Receptors, Purinergic P2X7

Source

Identifiers

PMID: 25983062
DOI: 10.1016/j.neurobiolaging.2015.03.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

P2X7 receptor is critical in α-synuclein--mediated microglial NADPH oxidase activation.PMID 25983062Read ↗

Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein.Semantic proximity Read ↗

The A53T mutation in α-synuclein enhances pro-inflammatory activation in human microgliaSemantic proximity Read ↗

The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis.Semantic proximity Read ↗

Angiotensin Type 1 Receptor Antagonists Protect Against Alpha-Synuclein-Induced Neuroinflammation and Dopaminergic Neuron Death.Semantic proximity Read ↗

Immunoregulation of Microglia M2 polarization is an unrecognized physiological function of α -SynucleinSemantic proximity Read ↗

Alpha-synuclein expression modulates microglial activation phenotype.Semantic proximity Read ↗

Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNSSemantic proximity Read ↗

Neuronal NADPH oxidase 2 in Parkinson’s disease pathogenesisSemantic proximity Read ↗

The P2X7 receptor: a new therapeutic target in Alzheimer’s diseaseSemantic proximity Read ↗

Expression of mutant alpha-synuclein modulates microglial phenotype in vitro.Semantic proximity Read ↗

The interplay between CB <sub>2</sub> and NMDA receptors in Parkinson’s diseaseSemantic proximity Read ↗

Hippocampal purinergic P2X7 receptor level is increased in Alzheimer’s disease patients, and associated with amyloid and tau pathologiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.