Article

Division state reveals hidden genetic regulation during T cell activation and identifies immune disease–linked gene programmes

2026-02-23

Abstract excerpt

A major challenge in human genetics is to connect disease-associated variants to the cellular functions they perturb. Variants associated with immune-mediated disease have implicated CD4⁺ T-cell activation as a disease-causal process; however, it remains unresolved whether these variants act on pathways initiating cell division, driving effector differentiation, or maintaining proliferative capacity. Activated T c...

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Literature Corpus work: 2713fcbb-2ad5-5b0f-ac9a-e4aeaee51333
DOI: 10.64898/2026.02.22.707277

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