Article

Connecting polygenic disease risk to cell states and regulatory programs through single-cell chromatin accessibility

2026-04-28

Abstract excerpt

Single-cell ATAC-sequencing enables high-resolution mapping of cell states and their putative regulatory elements. The enrichment of genome-wide association study (GWAS) signals within context-specific regulatory regions can reveal disease-relevant cell populations. We present Single-Cell ATAC-seq Disease Score (SCADS), a computational framework that integrates GWAS summary statistics with scATAC-seq data to prior...

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Literature Corpus work: 6fa25ab1-f9c5-5a14-b58c-b49cd7970965
DOI: 10.64898/2026.04.27.721080

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