Article

A multi-omics resource of B cell activation reveals genetic mechanisms for immune-mediated diseases

2025-05-23

Abstract excerpt

Most genetic variants that confer risk of complex immune-mediated diseases (IMDs) affect gene regulation in specific cell types. Their target genes and focus cell types are often unknown, partially because some effects are hidden in untested cell states. B cells play central roles in IMDs, including autoimmune, allergic, infectious, and cancer-related diseases. Despite this established importance, B cell activatio...

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Literature Corpus work: 04c2e2d4-4135-5e98-869c-d8c1d9a5a411
DOI: 10.1101/2025.05.22.25328104

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