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Article

Identifying genetic variants that influence the abundance of cell states in single-cell data.

Nature genetics - 1 Oct 2024

Rumker Laurie, Sakaue Saori, Reshef Yakir, Kang Joyce B, Yazar Seyhan, Alquicira-Hernandez Jose, Valencia Cristian, Lagattuta Kaitlyn A, Mah-Som Annelise, Nathan Aparna, Powell Joseph E, Loh Po-Ru, Raychaudhuri Soumya

Abstract excerpt

Disease risk alleles influence the composition of cells present in the body, but modeling genetic effects on the cell states revealed by single-cell profiling is difficult because variant-associated states may reflect diverse combinations of the profiled cell features that are challenging to predefine. We introduce Genotype-Neighborhood Associations (GeNA), a statistical tool to identify cell-state abundance...

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PMID: 39327486
DOI: 10.1038/s41588-024-01909-1

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