Article

Reproducible single cell annotation of programs underlying T-cell subsets, activation states, and functions

2024-05-05

Abstract excerpt

T-cells recognize antigens and induce specialized gene expression programs (GEPs) enabling functions including proliferation, cytotoxicity, and cytokine production. Traditionally, different classes of helper T-cells express mutually exclusive responses – for example, Th1, Th2, and Th17 programs. However, new single-cell RNA sequencing (scRNA-Seq) experiments have revealed a continuum of T-cell states without discr...

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Literature Corpus work: 1b55861a-f5d0-55c8-b88c-d1ae8e359a99
DOI: 10.1101/2024.05.03.592310

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