Article

Milo2.0 unlocks population genetic analyses of cell state abundance using a count-based mixed model

2023-11-11

Abstract excerpt

Cell type proportions vary between individuals and are heritable, as demonstrated by statistical genetic analysis of flow cytometry data [1,2]. Higher-resolution cell states can be identified by single-cell RNA-sequencing, the scalability of which now makes it applicable to population-scale cohorts. However, the integration of statistical genetic analysis of cell states using cohort-scale single-cell data requires...

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Literature Corpus work: bcd2e56b-fd34-56a0-bf73-7d391141fd79
DOI: 10.1101/2023.11.08.566176

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