Article

Time- and lineage-resolved transcriptional profiling uncovers gene expression programs and clonal relationships that underlie human T lineage specification

2023-10-10

Abstract excerpt

T cells develop from multi-potent hematopoietic progenitors in the thymus and provide adaptive protection against pathogens and cancer. However, the emergence of human T cell-competent blood progenitors, and their subsequent specification to the T lineage, has been challenging to capture in real time. Here, we leveraged a pluripotent stem cell differentiation system to understand the transcriptional dynamics and c...

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Literature Corpus work: f2df7a85-df66-5e31-98f6-8b225aeef002
DOI: 10.1101/2023.10.06.561277

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