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Article

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation.

Nature genetics - 1 Jun 2022

Soskic Blagoje, Cano-Gamez Kiki, Smyth Deborah J, Ambridge Kirsty, Ke Ziying, Matte Julie C, Bossini-Castillo Lara, Kaplanis Joanna, Ramirez-Navarro Lucia, Lorenc Anna, Nakic Nikolina, Esparza-Gordillo Jorge, Rowan Wendy, Wille David, Tough David F, Bronson Paola G, Trynka Gosia

Abstract excerpt

During activation, T cells undergo extensive gene expression changes that shape the properties of cells to exert their effector function. Understanding the regulation of this process could help explain how genetic variants predispose to immune diseases. Here, we mapped genetic effects on gene expression (expression quantitative trait loci (eQTLs)) using single-cell transcriptomics. We profiled 655,349 CD4+ T...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Immune System Diseases

Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 35618845
DOI: 10.1038/s41588-022-01066-3
PMCID: PMC9197762

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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