Article

Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data

2023-03-06

Abstract excerpt

<h4>Summary</h4> Advances in single-cell RNA sequencing (scRNA-seq) techniques have accelerated functional interpretation of disease-associated variants discovered from genome-wide association studies (GWASs). However, identification of trait-relevant cell populations is often impeded by inherent technical noise and high sparsity in scRNA-seq data. Here, we developed scPagwas, a computational approach that uncove...

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Literature Corpus work: fcff108f-55c1-5f6a-b699-69121c880cd6
DOI: 10.1101/2023.03.04.23286805

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