Article

<i>APOE</i> <sup>ε3/ε4</sup> and <i>APOE</i> <sup>ε4/ε4</sup> genotypes drive unique gene signatures in the cortex of young mice

2020-10-28

Abstract excerpt

<h4>Background</h4> Restrictions on mouse models have significantly impacted research towards understanding the most common genotype contributing to dementia in the human population – APOE ε3/ε4 . To address this, as part of MODEL-AD, we created new versions of humanized APOE ε4 and APOE ε3 mice on a C57BL/6J background that allow for unrestricted distribution and breeding. <h4>Methods</h4> To determine simi...

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Literature Corpus work: 264b6e3b-70a5-5e25-83f7-a1e2247bb554
DOI: 10.1101/2020.10.28.359422

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<i>APOE</i> <sup>ε3/ε4</sup> and <i>APOE</i> <sup>ε4/ε4</sup> genotypes drive unique gene signatures in the cortex of young miceDOI 10.1101/2020.10.28.359422Read

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