Article

Cholesterol and matrisome pathways dysregulated in human <i>APOE</i> ε4 glia

2019-07-25

Abstract excerpt

Apolipoprotein E ( APOE ) ε4 is the strongest genetic risk factor for Alzheimer’s disease (AD). Although its association with AD is well-established, the impact of APOE ε4 on human brain cell function remains unclear. Here we investigated the effects of APOE ε4 on several brain cell types derived from human induced pluripotent stem cells and human APOE targeted replacement mice. Gene set enrichment and pathway...

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Literature Corpus work: 8dabf0c5-3da8-5a12-aac1-872273a5cf0a
DOI: 10.1101/713362

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