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APOE ε4 and exercise interact in a sex‐specific manner to modulate dementia risk factors

1 Jan 2022

Abstract excerpt

Abstract Introduction Apolipoprotein E ( APOE ) ε4 is the strongest genetic risk factor for Alzheimer's disease and related dementias (ADRDs), affecting many different pathways that lead to cognitive decline. Exercise is one of the most widely proposed prevention and intervention strategies to mitigate risk and symptomology of ADRDs. Importantly, exercise and APOE ε4 affect similar processes in the body and...

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PMID: 35783454
DOI: 10.1002/trc2.12308

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