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Article

Apolipoprotein E ε4/4 genotype limits response to dietary induction of hyperhomocysteinemia and resulting inflammatory signaling.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 May 2022

Seaks Charles E, Weekman Erica M, Sudduth Tiffany L, Xie Kevin, Wasek Brandi, Fardo David W, Johnson Lance A, Bottiglieri Teodoro, Wilcock Donna M

Abstract excerpt

Vascular contributions to cognitive impairment and dementia (VCID) are the second leading cause of dementia behind Alzheimer's disease. Apolipoprotein E (ApoE) is a lipid transporting lipoprotein found within the brain and periphery. The APOE ε4 allele is the strongest genetic risk factor for late onset Alzheimer's disease and is a risk factor for VCID. Our lab has previously utilized a dietary model of...

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Identifiers

PMID: 35023380
DOI: 10.1177/0271678X211069006
PMCID: PMC9254035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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