Article

Rare genetic variation in Fibronectin 1 ( <i>FN1</i> ) protects against <i>APOEe4</i> in Alzheimer’s disease

2024-01-02

Abstract excerpt

The risk of developing Alzheimer’s disease (AD) significantly increases in individuals carrying the APOEε4 allele. Elderly cognitively healthy individuals with APOEε4 also exist, suggesting the presence of cellular mechanisms that counteract the pathological effects of APOEε4 ; however, these mechanisms are unknown. We hypothesized that APOEε4 carriers without dementia might carry genetic variations that could...

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Literature Corpus work: cd1eb00d-522e-544d-9f1a-7c0686618575
DOI: 10.1101/2024.01.02.573895

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