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APOEε4 and risk of Alzheimer’s disease – time to move forward

19 May 2023

Abstract excerpt

The inheritance of Apolipoprotein E4 (APOEε4) brings the highest genetic risk of Alzheimer’s disease (AD), arguably the highest genetic risk in human pathology. Since the discovery of the association, APOE protein isoforms have been at the center of tens of thousands of studies and reports. While, without a doubt, our knowledge about the normal physiological function of APOE isoforms in the brain has increased...

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PMID: 37274212
DOI: 10.3389/fnins.2023.1195724

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