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The APOEε3/ε4 Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice

16 Mar 2022

Abstract excerpt

Introduction Restrictions on existing APOE mouse models have impacted research toward understanding the strongest genetic risk factor contributing to Alzheimer’s disease (AD) and dementia, APOEε4, by hindering observation of a key, common genotype in humans – APOEε3/ε4. Human studies are typically underpowered to address APOEε4 allele risk as the APOEε4/ε4 genotype is rare, which leaves human and mouse research...

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PMID: 35370604
DOI: 10.3389/fnagi.2022.838436

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