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Article

Proteomic analysis of mice expressing human ApoE demonstrates no differences in global protein solubility between APOE 3 and APOE 4 young mice.

Electrophoresis - 1 Dec 2012

Londono Carolina, DeKroon Robert M, Mocanu Mihaela, Booe Jessica, Winnik Witold M, Swank Adam, Osorio Cristina, Hamlett Eric D, Alzate Oscar

Abstract excerpt

Apolipoprotein E (ApoE) is a major lipid carrier protein. In humans, ApoE is expressed in three polymorphic isoforms, which are encoded by three different alleles APOE2, APOE3, and APOE4. In the brains of Alzheimer's disease (AD) patients, each one of these three allelic isoforms is found in several "isoelectric" protein isoforms (qPI), i.e. protein isoforms resulting from PTMs altering the net charge (q) of the...

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Identifiers

PMID: 23161654
DOI: 10.1002/elps.201200219

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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