Article
Shift of the insoluble content of the proteome in aging mouse brain
2022-12-14
Abstract excerpt
Aging and protein aggregation diseases are inextricably linked. During aging, cellular response to unfolded proteins are believed to decline which results in diminished protein homeostasis (proteostasis). Indeed, in model organisms, such as C. elegans , proteostatic decline with age has even been linked to the onset of aggregation of proteins in wild-type animals. However, this correlation has not been extensivel...
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Identifiers and source
- Literature Corpus work
- 5117c133-aee0-5514-a6c0-4b2505dd63c0
- DOI
- 10.1101/2022.12.13.520290