Article

Quantitation of Spatial Proteoforms in Alzheimer’s Disease

2026-07-04

Abstract excerpt

Alzheimer’s disease (AD) pathogenesis involves complex, multifactorial changes to the brain proteome that conventional unfractionated analyses may obscure. Proteins frequently occupy multiple subcellular compartments as spatial proteoforms, yet the contribution of aberrant protein localization to AD pathogenesis remains poorly understood. To address this, we fractionated post-mortem human hippocampi from 13 AD and...

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Literature Corpus work: 39bf06d5-179d-525d-b2d4-9cdc26f2e93e
DOI: 10.64898/2026.06.30.735694

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