Article

Comparative study of protein aggregation propensity and mutation tolerance between naked mole-rat and mouse

2021-08-23

Abstract excerpt

The molecular mechanisms of aging and life expectancy have been studied in model organisms with short lifespans. However, long-lived species may provide insights into successful strategies of healthy aging, potentially opening the door for novel therapeutic interventions in age-related diseases. Notably, naked mole-rats, the longest-lived rodent, present attenuated aging phenotypes in comparison to mice. Their res...

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Literature Corpus work: 68746c08-bcbc-5f10-b6fd-288cda369424
DOI: 10.1101/2021.08.20.457120

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