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Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration

20 May 2022

Abstract excerpt

Aging is a prominent risk factor for neurodegenerative disorders (NDDs); however, the molecular mechanisms rendering the aged brain particularly susceptible to neurodegeneration remain unclear. Here, we aim to determine the link between physiological aging and NDDs by exploring protein turnover using metabolic labeling and quantitative pulse-SILAC proteomics. By comparing protein lifetimes between physiologically...

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PMID: 35594347
DOI: 10.1126/sciadv.abn4437

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