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Article

Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.

Acta neuropathologica - 1 Dec 2018

Pace Michael C, Xu Guilian, Fromholt Susan, Howard John, Crosby Keith, Giasson Benoit I, Lewis Jada, Borchelt David R

Abstract excerpt

The deposition of pathologic misfolded proteins in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, frontotemporal dementia and amyotrophic lateral sclerosis is hypothesized to burden protein homeostatic (proteostatic) machinery, potentially leading to insufficient capacity to maintain the proteome. This hypothesis has been supported by previous work in our laboratory, as evidenced by...

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Identifiers

PMID: 30140941
DOI: 10.1007/s00401-018-1895-y
PMCID: PMC6411038

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