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Article

Widespread remodeling of proteome solubility in response to different protein homeostasis stresses.

Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2020

Sui Xiaojing, Pires Douglas E V, Ormsby Angelique R, Cox Dezerae, Nie Shuai, Vecchi Giulia, Vendruscolo Michele, Ascher David B, Reid Gavin E, Hatters Danny M

Abstract excerpt

The accumulation of protein deposits in neurodegenerative diseases has been hypothesized to depend on a metastable subproteome vulnerable to aggregation. To investigate this phenomenon and the mechanisms that regulate it, we measured the solubility of the proteome in the mouse Neuro2a cell line under six different protein homeostasis stresses: 1) Huntington's disease proteotoxicity, 2) Hsp70, 3) Hsp90, 4)...

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Identifiers

PMID: 31964829
DOI: 10.1073/pnas.1912897117
PMCID: PMC7007570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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