Article

Paneth cells as the origin of intestinal cancer in the context of inflammation

2023-01-19

Abstract excerpt

<title>Abstract</title> <p>Paneth cells (PCs), responsible for the secretion of antimicrobial peptides in the small intestine and for niche support to Lgr5+ crypt-base columnar stem cells (CBCs), have been shown to respond to inflammation by dedifferentiating into stem-like cells in order to sustain a regenerative response<sup>1,2</sup>. Therefore, PCs may represent the cells-of-origin of intestinal cancer in the...

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Literature Corpus work: 7a3537ee-8bf0-556a-bcd2-06f9f2d325e5
DOI: 10.21203/rs.3.rs-2458794/v1

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