Article
Early mutational events and clonal dynamics in normal crypts: implications for colorectal tumorigenesis.
Human genomics - 15 Dec 2025
Marvalim Charlie, Chan Dedrick Kok Hong
Abstract excerpt
Colorectal cancer has widely been described by the classic adenoma-carcinoma sequence, where sequential mutations in APC, KRAS, and TP53 drive the transition from normal epithelium to carcinoma. However, recent high-resolution genomic analyses have expanded this framework by revealing the presence of multiple driver mutations within morphologically normal colonic crypts. In this review, we summarize the emerging...
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