Article

Oncogenic signalling is coupled to colorectal cancer cell differentiation state

2022-04-08

Abstract excerpt

Colorectal cancer progression is intrinsically linked to stepwise deregulation of the intestinal differentiation trajectory. In this process, sequential mutations of APC/Wnt, KRAS, TP53 and SMAD4 stepwisely enable an oncogenic signalling network. Here, we developed a novel mass cytometry antibody panel to analyse colorectal cancer cell differentiation and signalling in human isogenic colorectal cancer organoids an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 27175eae-61f2-5298-8d12-436345dc3ffa
DOI: 10.1101/2022.04.07.487491

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oncogenic signalling is coupled to colorectal cancer cell differentiation stateDOI 10.1101/2022.04.07.487491Read

Oncogenic signaling is coupled to colorectal cancer cell differentiation state.Semantic proximity Read

Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixtureSemantic proximity Read

An oncogenic phenoscape of colonic stem cell polarizationSemantic proximity Read

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epitheliumSemantic proximity Read

Perturbation-guided mapping of colorectal cancer cell states to causal mechanismsSemantic proximity Read

Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiationSemantic proximity Read

Advances in Colorectal Cancer Cell Biology and Clonal Evolution.Semantic proximity Read

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epitheliumSemantic proximity Read

Revealing unidentified heterogeneity in different epithelial cancers using heterocellular subtype classificationSemantic proximity Read

Epithelial-to-mesenchymal transition signature assessment in colorectal cancer quantifies tumour stromal content rather than true transition.Semantic proximity Read

Epigenetic evolution of colorectal cancer and its microenvironment reveals new vulnerabilitiesSemantic proximity Read

Human colon organoids reveal distinct physiologic and oncogenic Wnt responsesSemantic proximity Read