Article

Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation

2022-09-23

Abstract excerpt

<h4>ABSTRACT</h4> Cell state (phenotypic) plasticity is a carefully regulated feature of adult epithelial cells that enables adaptive responses to injury, inflammation, and other forms of stress. Aberrant expansion of the normally restricted capability for cell state plasticity to escape terminal differentiation is a critical aspect of neoplasia. The nongenetic factors and specific programs that mediate aberrant...

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Literature Corpus work: 0156a6e7-2013-5972-a67e-e5f083a9cb4c
DOI: 10.1101/2022.09.22.509032

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