Article

Colon cancer arises from differentiated cell lineages in the context of inflammation

2023-10-04

Abstract excerpt

According to conventional views, colon cancer originates from stem cells. However, inflammation, a key risk factor for colon cancer, was shown to suppress intestinal stemness. Here, we employed Paneth cells (PCs) as a model to assess the capacity of differentiated lineages to trigger tumorigenesis in the context of inflammation. Upon inflammation, PC-specific Apc mutations led to intestinal tumors reminiscent not...

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Literature Corpus work: ea49746e-1c10-5bb6-8fcf-ee19dfa56282
DOI: 10.1101/2023.10.02.560432

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