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Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture

2022-06-12

Abstract excerpt

Intestinal homeostasis is underpinned by LGR5+ve crypt-base columnar stem cells (CBCs), but following injury, dedifferentiation results in the emergence of LGR5-ve regenerative stem cell populations (RSCs), characterised by fetal transcriptional profiles. Neoplasia hijacks regenerative signalling, so we assessed the distribution of CBCs and RSCs in mouse and human intestinal tumors. Using combined molecular-morp...

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Literature Corpus work
b16af5a7-b7f0-5142-b85a-cfa2d885c3fa
DOI
10.1101/2022.06.11.495729
Open publication

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Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixtureDOI 10.1101/2022.06.11.495729
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