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Article

Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers.

Genes, chromosomes & cancer - 1 Jul 2018

Wolff Roger K, Hoffman Michael D, Wolff Erica C, Herrick Jennifer S, Sakoda Lori C, Samowitz Wade S, Slattery Martha L

Abstract excerpt

Colorectal cancer (CRC) accounts for about 8% of all new cancer cases diagnosed in the US. We used whole exome sequence data from triplet samples (colon carcinoma, colon adenoma, and normal tissue) from 18 individuals to assess gene mutation rates. Of the 2 204 genes that were mutated, APC, TTN, TP53, KRAS, OBSCN, SOX9, PCDH17, SIGLEC10, MYH6, and BRD9 were consistent with genes being an early driver of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29575536
DOI: 10.1002/gcc.22539
PMCID: PMC5951744

Genes

APC
KRAS
ATM
BRD9
CSMD3
MUC17
MYH6
OBSCN
PCDH17
RYR2
SIGLEC10
SOX9
TTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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