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Article

Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury.

Neoplasia (New York, N.Y.) - 1 May 2021

Chen Tiane, Zeineldin Maged, Johnson Blake A, Dong Yi, Narkar Akshay, Li Taibo, Zhu Jin, Li Rong, Larman Tatianna C

Abstract excerpt

Although much is known about the gene mutations required to drive colorectal cancer (CRC) initiation, the tissue-specific selective microenvironments in which neoplasia arises remains less characterized. Here, we determined whether modulation of intestinal stem cell niche morphogens alone can exert a neoplasia-relevant selective pressure on normal colonic epithelium. Using adult stem cell-derived murine colonic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33906087
DOI: 10.1016/j.neo.2021.03.010
PMCID: PMC8099723

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