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An oncogenic phenoscape of colonic stem cell polarization

1 Dec 2023

Abstract excerpt

Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet these processes are often studied separately. To functionally map how cell-intrinsic and cell-extrinsic cues co-regulate cell fate, we performed a systematic single-cell analysis of 1,107 colonic organoid cultures regulated by (1) colorectal cancer (CRC) oncogenic mutations, (2) microenvironmental fibroblasts and macrophages,...

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PMID: 38065080
DOI: 10.1016/j.cell.2023.11.004

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