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BMP signalling in colorectal cancer: losing the yin to WNTs yang

11 Apr 2025

Abstract excerpt

Colorectal cancer (CRC) is the third most common form of cancer globally, and arises from the hyperproliferation of epithelial cells in the intestine. The architecture and maintenance of these cells is governed by two major signalling pathways working in a counter-gradient: the stem cell WNT signalling pathway, and the prodifferentiation bone morphogenetic protein (BMP) pathway. It has long been known that this...

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PMID: 40212011
DOI: 10.1002/path.6428

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