Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility.

doi:10.1038/ni.2937

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility.

Nature immunology - 1 Aug 2014

Seumois Grégory, Chavez Lukas, Gerasimova Anna, Lienhard Matthias, Omran Nada, Kalinke Lukas, Vedanayagam Maria, Ganesan Asha Purnima V, Chawla Ashu, Djukanović Ratko, Ansel K Mark, Peters Bjoern, Rao Anjana, Vijayanand Pandurangan

Abstract excerpt

A characteristic feature of asthma is the aberrant accumulation, differentiation or function of memory CD4(+) T cells that produce type 2 cytokines (TH2 cells). By mapping genome-wide histone modification profiles for subsets of T cells isolated from peripheral blood of healthy and asthmatic individuals, we identified enhancers with known and potential roles in the normal differentiation of human TH1 cells and...

Topics

Adolescent
Adult
Aged
Asthma
Binding Sites
Cell Differentiation
Cells, Cultured
Core Binding Factor Alpha 3 Subunit
DNA Methylation
Epigenomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

GATA3 Transcription Factor

Genetic Predisposition to Disease

Genome-Wide Association Study

Histones

Humans

Immunologic Memory

Male

Source

Open in PubMed Open full text

Identifiers

PMID: 24997565
DOI: 10.1038/ni.2937
PMCID: PMC4140783

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility.PMID 24997565Read ↗

Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization.Semantic proximity Read ↗

Integration of genetic and epigenetic data pinpoints autoimmune specific remodelling of enhancer landscape in CD4+ T cellsSemantic proximity Read ↗

Epigenetic regulation of T‐helper cell differentiation, memory, and plasticity in allergic asthmaSemantic proximity Read ↗

An enhancer-centric approach applied to human immune system epigenomes revealed the association of macrophage enhancers with cardiovascular diseaseSemantic proximity Read ↗

Integration of genetic and chromatin modification data pinpoints autoimmune-specific remodeling of enhancer landscape in CD4+ T cells.Semantic proximity Read ↗

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.Semantic proximity Read ↗

Systems-level identification of key transcription factors in immune cell specificationSemantic proximity Read ↗

Understanding the role of CD4+ T cells in common immune-mediated diseasesSemantic proximity Read ↗

Epigenome analysis links gene regulatory elements in group 2 innate lymphocytes to asthma susceptibility.Semantic proximity Read ↗

Linking candidate causal autoimmune variants to T cell networks using genetic and epigenetic screens in primary human T cellsSemantic proximity Read ↗

Chromatin remodeling and T helper subset differentiation.Semantic proximity Read ↗

Chromatin activity at GWAS loci identifies T cell states driving complex immune diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.