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Article

Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility.

Nature immunology - 1 Aug 2014

Seumois Grégory, Chavez Lukas, Gerasimova Anna, Lienhard Matthias, Omran Nada, Kalinke Lukas, Vedanayagam Maria, Ganesan Asha Purnima V, Chawla Ashu, Djukanović Ratko, Ansel K Mark, Peters Bjoern, Rao Anjana, Vijayanand Pandurangan

Abstract excerpt

A characteristic feature of asthma is the aberrant accumulation, differentiation or function of memory CD4(+) T cells that produce type 2 cytokines (TH2 cells). By mapping genome-wide histone modification profiles for subsets of T cells isolated from peripheral blood of healthy and asthmatic individuals, we identified enhancers with known and potential roles in the normal differentiation of human TH1 cells and...

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Identifiers

PMID: 24997565
DOI: 10.1038/ni.2937
PMCID: PMC4140783

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CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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