Article

Understanding the role of CD4+ T cells in common immune-mediated diseases

2021-01-01

Abstract excerpt

Immune-mediated diseases such as autoimmunity are complex traits which collectively affect around 10% of the European population. Genome-wide association studies (GWAS) have demonstrated that genetic susceptibility to these diseases is explained by thousands of loci spread throughout the genome, most of which lie within non-coding DNA. Moreover, these loci are enriched in CD4+ T cell regulatory elements, which sug...

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Literature Corpus work: 0629565d-2ef8-5ffc-87c1-77ad8aab5df1
DOI: 10.17863/cam.70885

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