Article

The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory states

2022-02-26

Abstract excerpt

Th17 cells are a heterogenous cell population consisting of non-pathogenic Th17 cells (npTh17) that contribute to tissue homeostasis and pathogenic Th17 cells (pTh17) that are potent mediators of tissue inflammation. To reveal regulatory mechanisms underlying Th17 heterogeneity, we performed combined ATAC-seq and RNA-seq and discovered substantial differences in the chromatin landscape of npTh17 and pTh17 cells bo...

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Literature Corpus work: e0f492da-38cc-556a-8c3d-8e8476b5bf53
DOI: 10.1101/2022.02.26.482041

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