Article

Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple AD ligands

2024-05-27

Abstract excerpt

TREM2 is a signaling receptor expressed on microglia that has emerged as an important potential drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 signaling ligands have been identified, little is known regarding the structural details of how it engages them. To better understand this, we created a protein library of 28 different TREM2 variants and 11 different sTREM2...

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Literature Corpus work: 247fc2a1-a399-5ffa-9627-87fa74918b0e
DOI: 10.1101/2024.05.23.595592

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