Article

The flexible stalk domain of sTREM2 modulates its interactions with brain-based phospholipids

2024-09-07

Abstract excerpt

The microglial surface protein Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) plays a critical role in mediating brain homeostasis and inflammatory responses in Alzheimer’s disease (AD). The soluble form of TREM2 (sTREM2) exhibits neuroprotective effects in AD, though the underlying mechanisms remain elusive. Moreover, differences in ligand binding between TREM2 and sTREM2, which have major implications...

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Literature Corpus work: eff618fe-3121-58ca-8e0e-d5a43edda751
DOI: 10.1101/2024.09.04.611223

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